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miRNAs Profiling in Parkinson's Disease

NCT03466723 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2023-03-23

No results posted yet for this study

Summary

microRNAs (miRNAs) regulate fundamental cell processes. Dysregulation of miRNA expression and function is reported in various diseases including cancer, metabolic disorders as well as neurological disorders. Circulating miRNAs have been proposed to mirror physiological and pathological conditions suggesting their use as biomarkers for various diseases. The study will focus on a case-control study cohort (N=1000) of subjects recruited at the IRCCS Neuromed for which a deep clinical characterization and genome-wide sequencing data are available. This study will enable to identify novel circulating biomarkers for Parkinson's disease (PD). Further, the project will give new insights on the involvement of miRNAs in the etiology of PD and in the understanding of the genetics of the disease thus opening avenues for novel therapeutic strategies.

Conditions

  • Parkinson Disease

Interventions

GENETIC

biomarker identification in Parkinson disease

circulating miRNAs profiling by NGS analysis functional miRNA characterization association of miRNA levels with genetic variants

Sponsors & Collaborators

  • Neuromed IRCCS

    lead OTHER

Principal Investigators

  • Daniela Ruggiero, Ph.D. · Neuromed IRCCS

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-02-14
Primary Completion
2020-12-14
Completion
2022-06-14

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03466723 on ClinicalTrials.gov