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Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation

NCT03464175 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2022-11-04

No results posted yet for this study

Summary

The intention is to enroll a specific sample of intubated patients. To compare the effect of respiratory gas conditioning on lung deposition and considering the well-known influences of lung pathology on lung deposition, intubated patients with healthy lungs will be included. Postoperative neurosurgery ventilated patients respond perfectly to this criteria. A previous study including 17 postoperative neurosurgery patients was performed in 2013 with a perfect collaboration between the ICU and the Department of Neurosurgery and Anesthesiology.

Conditions

  • Brain Injuries, Traumatic

Interventions

DEVICE

Aerogen Solo®

Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation

DEVICE

Heated-humidified circuit

It will be left on during the transfer and the nebulization in group 1

DEVICE

Heated-humidified circuit

It will be turned off 30 minutes before the nebulization (nebulization ended max 45 minutes after turning off the heated-humidifier).

DEVICE

Dry ventilator circuit specific for aerosol therapy

Streamlined components, specific position for the nebulizer at 30 cm of a V-shaped Y piece

DEVICE

Conventional dry ventilator circuit with HME filter

The nebulizer is placed between the filter and the endotracheal tube.

Sponsors & Collaborators

  • Cliniques universitaires Saint-Luc- Université Catholique de Louvain

    lead OTHER

Principal Investigators

  • Pierre-François Laterre, MD, PhD · Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-22
Primary Completion
2020-12-15
Completion
2020-12-15

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03464175 on ClinicalTrials.gov