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To Determine the Effect of GLP1 on Cognitive Function, Brain Glucose Metabolism and Neuroplasticity.

NCT03414333 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2018-07-19

No results posted yet for this study

Summary

To test the hypothesis that GLP1 can exert favourable effects on multiple aspects of brain function. To this purpose, the investigator determine whether chronic increase in GLP1 concentration as it occurs after bariatric surgery (Roux-en- Y Gastric Bypass) is associated with improvement in:

* cognitive function measured by Mini Mental State Examination (MMSE) and Mental Deterioration Battery(MDB).
* brain glucose metabolism measured by FDG-CT/PET
* neuroplasticity measure by binocular rivalry and saccadic adaptation tests in morbid obese subjects. In order to discern the effect of GLP1 irrespective of changes in the metabolic milieu the investigator will test whether short-term GLP-1 infusion can modulate the same parameters in healthy subjects.

Conditions

  • Glucose Metabolism Disorders
  • Obesity
  • Degenerative Brain Disorder

Interventions

PROCEDURE

RYGB

RYGB is associated with a increase of circulating GLP-1 (up to ten-fold) especially in response to meal ingestion. This increased availability of GLP1 has been claimed to contribute to restoration of some of the beta-cell function.

DRUG

GLP-1

GLP-1 is an hormone secreted by gut in response to nutrients ingestion.

Sponsors & Collaborators

  • University of Pisa

    lead OTHER

Principal Investigators

  • Stefano Del Prato, MD · University of Pisa

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-06-29
Primary Completion
2017-06-30
Completion
2018-06-30

Countries

  • Italy

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03414333 on ClinicalTrials.gov