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The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity

NCT01918566 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2013-08-07

No results posted yet for this study

Summary

Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.

Conditions

  • Exploratory Behavior

Interventions

DIETARY_SUPPLEMENT

tap water

DIETARY_SUPPLEMENT

Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube

DIETARY_SUPPLEMENT

Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole

DIETARY_SUPPLEMENT

25g Fructose in 300ml tap water

DIETARY_SUPPLEMENT

75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39

DIETARY_SUPPLEMENT

300ml tap water with 450ppm lactisole

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Christoph Beglinger, MD · University Hospital, Basel, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-03-31
Primary Completion
2013-03-31
Completion
2013-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01918566 on ClinicalTrials.gov