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Research of Intensive Metabolic Intervention Before Pregnancy in PCOS

NCT03383068 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2017-12-26

No results posted yet for this study

Summary

To investigate whether intensive metabolic intervention of PCOS women before pregnancy can improve pregnancy outcome.Besides, the investigators aim to investigate the best therapy strategy of metabolic intervention before pregnancy.The investigators plan to recruit PCOS women at childbearing age. By using acarbose, GLP-1 analogue, berberin et al. the investigators will intervent the participants' metabolic statues for 3 months before pregnancy and to compare outcome in each group.

Conditions

  • PCOS
  • Impaired Glucose Tolerance

Interventions

DRUG

Acarbose 100 MG

for metformin uneffective subjects, using acarbose for 3 months

DRUG

Exenatide

for metformin uneffective subjects, using Exenatide for 3 months

DRUG

Orlistat

for metformin uneffective subjects, using Orlistatfor 3 months

DRUG

Metformin

metformin effective subjects,act as control group

Sponsors & Collaborators

  • RenJi Hospital

    lead OTHER

Principal Investigators

  • Tao Tao, MD · RenJi Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2018-12-31
Completion
2020-06-30

Countries

  • China

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03383068 on ClinicalTrials.gov