MedTrace Logo

The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals

NCT03326648 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2018-04-11

No results posted yet for this study

Summary

The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors are affected by strength training and protein supplementation. It is already established that muscle quality defined as the ratio between the strength and the size of a muscle is improved with strength training, even in frail elderly individuals. However, the relative contribution of factors such as activation level, fat infiltration, muscle architecture and single fiber function is unknown. The main focus of this study is to investigate the relationship between muscle quality and muscle protein breakdown, as insufficient degradation of proteins is hypothesized to negatively affect muscle quality.

Conditions

Interventions

OTHER

Strength training

Heavy load strength training performed twice a week for 10 weeks.

DIETARY_SUPPLEMENT

Protein supplementation

Dietary protein supplement (protein-enriched milk with 0,2 % fat). 0,33 l each day for 10 weeks.

Sponsors & Collaborators

  • University of Padova

    collaborator OTHER

  • University of Copenhagen

    collaborator OTHER

  • Tine

    collaborator INDUSTRY

  • Truls Raastad

    lead OTHER

Principal Investigators

  • Truls Raastad, Prof. · Norwegian School of Sport Sciences

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-09-01
Primary Completion
2017-12-20
Completion
2018-03-01

Countries

  • Norway

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03326648 on ClinicalTrials.gov