Sarcopenia Prevention With a Targeted Exercise and Protein Supplementation Program

Summary

Physical inactivity and protein malnutrition have been implicated to be key and modifiable causes of enhanced muscle mass loss among seniors. However, the individual benefit, as well as the additive or possibly interactive benefit of exercise and Protein supplementation on fall prevention has yet to be confirmed in a large clinical trial. This study aims to test the individual and combined effect and cost-effectiveness of a simple home exercise program and / or protein supplementation on the risk of falling in seniors at high risk of progressive muscle mass loss and sarcopenia.

Conditions

• Sarcopenia
• Frailty
• Malnutrition; Protein
• Fall

Interventions

DIETARY_SUPPLEMENT

Protein Supplement

Predosed protein powder; can be added to various dishes and drinks

DIETARY_SUPPLEMENT

Protein-free Supplement

Predosed protein-free powder; can be added to various dishes and drinks

PROCEDURE

Active Exercise

Program includes five strength exercises that can be easily performed at home

PROCEDURE

Control Exercise

Program includes five flexibility exercises that can be easily performed at home

Sponsors & Collaborators

• Swiss National Science Foundation

  collaborator OTHER

• University Hospital, Zürich

  collaborator OTHER

• University Geriatric Medicine Felix Platter, Basel, Switzerland

  collaborator UNKNOWN

• Omanda AG, Baar, Switzerland

  collaborator UNKNOWN

• Ferrari Data Solution

  collaborator OTHER

• City Hospital Waid and Triemli, Zurich, Switzerland

  collaborator UNKNOWN

• Cantonal Hospital of St. Gallen

  collaborator OTHER

• University Hospital, Basel, Switzerland

  collaborator OTHER

• University of Zurich

  lead OTHER

Principal Investigators

• Heike A. Bischoff-Ferrari, MD, DrPH · University of Basel

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

FACTORIAL

Eligibility

Min Age

75 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-06-25

Primary Completion

2025-03-24

Completion

2025-03-24

Countries

• Switzerland

Study Locations