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Surveillance of Patients With Precancerous Lesions of the Stomach

NCT03250091 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2018-08-21

No results posted yet for this study

Summary

The project will aim to identify and determine subgroups of patients with different risks of progression to gastric cancer and to assess appropriate follow-up intervals. Implementing risk stratification only high risk individuals will be offered and performed endoscopic surveillance.

Conditions

  • Gastric Cancer
  • Gastric Intestinal Metaplasia
  • Gastric Atrophy
  • Gastric Dysplasia

Interventions

PROCEDURE

Upper endoscopy with biopsies

Upper endoscopy with proper biopsy work-up will be used for identification and stratification of gastric lesions as well as acquisition of biopsies for histopathological examination, including H.pylori detection

PROCEDURE

Plasma/serum sampling

Plasma/serum sampling will be used to obtain information for group stratification, e.g. H.pylori status determination, serum biomarkers

PROCEDURE

Biopsies for gastric microbiota

During upper endoscopy biopsies for gastric microbiota analysis will be obtained

PROCEDURE

Faecal sample acquisition

Faecal samples will be obtained for faecal occult blood testing as well as microbiota analysis

Sponsors & Collaborators

  • Digestive Diseases Centre GASTRO

    collaborator OTHER

  • Riga East Clinical University Hospital

    collaborator OTHER_GOV

  • Academic Histology Laboratory (Latvia)

    collaborator OTHER

  • University of Latvia

    lead OTHER

Principal Investigators

  • Marcis Leja, Prof.,PhD · Institute of Clinical and Preventive Medicine, University of Latvia

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-19
Primary Completion
2027-05-31
Completion
2027-12-31

Countries

  • Latvia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03250091 on ClinicalTrials.gov