The EpiGASTRIC/EDGAR Project: New Strategies for the Early Detection and Prevention of Gastric Cancer

Summary

This study is a multicenter, prospective cohort study, which are planned to enroll at least 600 patients who diagnosed the primary gastric cancer (GC); around 50 patients with premalignant gastric lesions (PGLs) and early gastric neoplasias (EGC) treated by endoscopy resection; and no less than 600 healthy normal cohort participants, for more than 18 months in the Spanish population. All participants who enrolled in this registry will be questioned by the life habits survey; and clinical data and biological samples of these participants were analyzed in order to look for new diagnostic tools.

The aim of this study is to evaluate clinical, endoscopic and molecular approaches to identify individuals with high-risk of GC. Thus, it would be allow the adoption of preventive measures to reduce mortality through early detection and/or the reduction of its incidence.

Conditions

• Gastric Neoplasms
• Gastric Cancer
• Gastric Lesion

Interventions

OTHER

Identification of risk factors

Demographics, life habits and risk factors studies

OTHER

Characterization of premalignant gastric lesions

Identification and characterization of premalignant gastric lesions through high definition endoscopic study. Concordance between endoscopic and histological classifications

OTHER

Identification of biomarkers

Multiomic studies

OTHER

Identification of gastric cancer hereditary predisposition

Genomic studies for the identification of individuals with hereditary GC predisposition

Sponsors & Collaborators

• Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain

  collaborator UNKNOWN

• Fundació Clínic per a la Recerca Biomèdica (FCRB), Spain

  collaborator UNKNOWN

• Miguel Servet Foundation/Navarrabiomed, Spain

  collaborator UNKNOWN

• Barcelona Clinic Hospital (HCB), Spain

  collaborator UNKNOWN

• Navarre University Hospital (HUN), Spain

  collaborator UNKNOWN

• Navarre Health Research Institute (IdiSNA), Spain

  collaborator UNKNOWN

• Carlos III Health Institute (ISCIII), Spain

  collaborator UNKNOWN

• Spanish Society of Digestive Endoscopy (SEED) Foundation

  collaborator UNKNOWN

• Spanish Association of Gastroenterology (AEG)

  collaborator UNKNOWN

• EDUARDO ALBENIZ

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-09-09

Primary Completion

2025-09-30

Completion

2026-12-31

Countries

• Spain

Study Locations