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Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa

NCT03231358 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 1758

Last updated 2025-05-15

Study results available
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Summary

The purpose of this study is to test the efficacy of Our Family Our Future, an integrated intervention for preventing HIV and depression onset among adolescents.

Conditions

  • Human Immunodeficiency Virus
  • Depression
  • Sexually Transmitted Diseases

Interventions

BEHAVIORAL

Our Family Our Future

Our Family Our Future is a 'selective' behavioral prevention program, designed to address HIV/STI acquisition, sexual risk behavior, and depression among adolescents (ages 14-16) in communities with high HIV prevalence and from families where adolescents and parents already exhibit mild, potentially troublesome, depressive symptoms but do not reach the threshold for further screening for a significant clinical depressive disorder. Participants receive the intervention in a community setting, in a facilitated group format. The intervention is comprised of 3-hour sessions, held weekly for 3 consecutive weeks with an individual family meeting in the third or fourth week depending on family desires.

Sponsors & Collaborators

  • University of Cape Town

    collaborator OTHER

  • Desmond Tutu HIV Foundation

    collaborator OTHER

  • Medical Research Council, South Africa

    collaborator OTHER

  • Rhode Island Hospital

    collaborator OTHER

  • Brown University

    lead OTHER

Principal Investigators

  • Caroline Kuo, DPhil, MPhil · Brown University

  • Linda-Gail Bekker, MBChB, PhD · Desmond Tutu HIV Foundation

  • Dan J Stein, MBChB, PhD · University of Cape Town

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
14 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-21
Primary Completion
2022-08-31
Completion
2024-07-31

Countries

  • South Africa

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03231358 on ClinicalTrials.gov