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PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis

NCT03215550 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2020-02-11

No results posted yet for this study

Summary

Ischaemic stroke is a major cause of death and disability worldwide. In patients with recent stroke, the 18F-fluoride positron emission tomography-computed tomography highlights high-risk culprit carotid plaque and is more discriminatory than 18F-fluorodeoxyglucose. Using hybrid positron emission tomography-magnetic resonance imaging investigators propose to build upon these findings by prospectively assessing 18F-fluoride uptake in a broad range of patients with acute transient ischaemic attack or ischaemic stroke. Investigators will specifically examine the association of 18F-fluoride uptake with multiparametric magnetic resonance imaging assessments of atherosclerotic plaque, especially the role of thrombus and lipid. Finally, using transcranial Doppler and diffusion-weighted magnetic resonance brain imaging, an assessment of the functional consequences of 18F-fluoride-positive atherosclerotic plaque will be performed. If successful, this technique has a number of valuable translational applications including the better selection of patients for carotid intervention.

Conditions

Interventions

PROCEDURE

CEA

Carotid Endarterectomy

RADIATION

18F PET-MRI

18F-fluoride Hybrid PET-MRI

DIAGNOSTIC_TEST

Transcranial Doppler

Microembolic Signals detection

Sponsors & Collaborators

  • University of Edinburgh

    lead OTHER

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-10-12
Primary Completion
2020-01-10
Completion
2020-01-10

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03215550 on ClinicalTrials.gov