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Childhood Acute Illness and Nutrition Network

NCT03208725 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 4335

Last updated 2020-05-20

No results posted yet for this study

Summary

The CHAIN Network aims to identify modifiable biomedical and social factors driving the greatly increased risk of mortality among young undernourished children admitted to hospital with acute illness, as inpatients and after discharge. The study will inform priorities, risks and targeting for multi-faceted interventional trials.

CHAIN is a multi-centre cohort study with a nested case control analysis of stored biological samples. Study sites are located in Africa and South Asia. Children will be recruited at admission to hospital, stratified by nutritional status. Exposures will be assessed at admission, during hospitalisation, at discharge, and at two time points after discharge. The main outcomes of interest are mortality, re-admission to hospital and failure of nutritional recovery up to 180 days after discharge. To determine community health norms, an additional sample of children living in the same communities will be enrolled and assessed at one time point only.

Conditions

Sponsors & Collaborators

  • University of Washington

    collaborator OTHER

  • Kenya Medical Research Institute

    collaborator OTHER

  • KEMRI-Wellcome Trust Collaborative Research Program

    collaborator OTHER

  • Makerere University

    collaborator OTHER

  • Oregon Health and Science University

    collaborator OTHER

  • The Hospital for Sick Children

    collaborator OTHER

  • University of Amsterdam

    collaborator OTHER

  • University of Malawi

    collaborator OTHER

  • Aga Khan University

    collaborator OTHER

  • International Centre for Diarrhoeal Disease Research, Bangladesh

    collaborator OTHER

  • University of Oxford

    lead OTHER

Principal Investigators

  • James A Berkley, MBBS, FRCPCH · University of Oxford

  • Judd L Wilson, MD, MPH · University of Washington

Eligibility

Min Age
2 Months
Max Age
23 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-11-30
Primary Completion
2020-01-31
Completion
2020-10-31

Countries

  • Bangladesh
  • Kenya
  • Malawi
  • Pakistan
  • Uganda

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03208725 on ClinicalTrials.gov