Understanding the Late Effects of Surviving a Pediatric Brain Tumor

Summary

The goal of this study is to learn about the cognitive and behavioral functioning of children being treated for cancer.

Conditions

• Brain Tumor
• Pediatric Brain Tumor
• Pediatric Cancer

Interventions

DIAGNOSTIC_TEST

Diffusion tensor imaging (DTI)

DTI quantifies the degree to which water diffuses in different directions through a given brain region. The use of DTI as an in vivo index of the integrity of white matter has been applied to many disease states using several proprietary and open-source software programs (e.g. FSL 5.0). DTI tractography, employed via toolboxes such as Probtrackx within the FSL 5.0, allows the identification of white matter tracts connecting cortical and subcortical regions of interest. Furthermore, structural connectivity as measured with DTI does not duplicate functional connectivity as measure with rs-fcMRI, but rather provides complimentary perspectives.

DIAGNOSTIC_TEST

Resting state functional connectivity MRI (rs-fcMRI)

rs-fcMRI is a relatively new neuroimaging technique that has been applied to studying multiple clinical populations including ADHD, schizophrenia, major depressive disorder, and other neurological disorders. The approach exploits measurement of changes in brain blood oxygenation (BOLD) as is employed in task based functional MRI (measuring changes in focal cortical vascular oxygenation when engaged in a defined task, e.g. motor movement). Neuroimaging data will be collected as soon as possible (can be the same day), for up to 6 weeks.

BEHAVIORAL

Wechsler Intelligence Scale for Children - 5th edition (WISC-V)

Will gather IQ data and is the gold standard for IQ assessment for those between the ages of 6:0 and 16:11 years.

BEHAVIORAL

California Verbal Learning Test (CVLT-C)

Validated measure of verbal learning and memory for those between the ages of 5:0 and 16:11.

BEHAVIORAL

Beery Test of Visual Motor Integration 6th edition

Measure designed to assess visual-motor functioning of subjects between the ages of 2-99 years old by copying designs using paper and pencil.

BEHAVIORAL

Grooved Pegboard

This is a standard assessment of fine motor functioning and dexterity by asking the subject to place metal pegs into holes on a board.

BEHAVIORAL

PedsQL Multidimensional Fatigue Scale

Designed to measure fatigue in pediatric patients (ages 5-17 years) and is comprised of the General Fatigue Scale (6 items), Sleep/Rest Fatigue Scale (6 items) and Cognitive Fatigue Scale (6 items).

DIAGNOSTIC_TEST

MRI

Images will be acquired on a 3.0 Tesla MRI scanner at each of the four study sites. At MSK, resting state fMRI data will be obtained using a 3T GE scanner with an 8-channel head coil (Discovery 750w DV25)

Sponsors & Collaborators

• Columbia University

  collaborator OTHER

• University of Washington

  collaborator OTHER

• University of Texas

  collaborator OTHER

• Rutgers University

  collaborator OTHER

• Memorial Sloan Kettering Cancer Center

  lead OTHER

Principal Investigators

• Stephen Sands, PsyD · Memorial Sloan Kettering Cancer Center

Eligibility

Min Age

6 Years

Max Age

16 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-06-28

Primary Completion

2026-06-30

Completion

2026-06-30

Countries

• United States

Study Locations