Clinical Trial of Metastasis Inhibitor NP-G2-044 in Patients With Advanced or Metastatic Treatment-Refractory Solid Tumor Malignancies
NCT03199586 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 23
Last updated 2025-07-20
Summary
Phase 1 A: First-in-human phase 1 study to determine safety of NP-G2-044 when given orally on a daily X 28 days followed by a 14 day rest period.
Conditions
- Breast Cancer
- Pancreas Cancer
- Prostate Cancer
- Lung Cancer
- Colon Cancer
- Esophagus Cancer
- Liver Cancer
- Ovary Cancer
- Advanced or Metastatic Treatment-refractory Solid Tumor Malignancies
Interventions
- DRUG
-
NP-G2-044
capsule
Sponsors & Collaborators
-
Translational Drug Development
collaborator OTHER -
Novita Pharmaceuticals, Inc.
lead INDUSTRY
Principal Investigators
-
Jillian Zhang, Ph.D. · Novita Pharmaceuticals
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-12-21
- Primary Completion
- 2020-05-07
- Completion
- 2020-05-07
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Combretastatin A4 Phosphate in Treating Patients With Advanced Solid Tumors
NCT00003768 ·Status: COMPLETED ·Phase: PHASE1
-
Phenylbutyrate in Treating Patients With Refractory Solid Tumors or Lymphoma
NCT00002909 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study to Determine Absorption, Distribution, Metabolism, and Elimination of a Single Radiolabeled Dose of Brivanib (BMS-582664)
NCT00435669 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Investigate the Effect of Food on Oral LBH589 Absorption in Patients With Advanced Solid Tumors
NCT00570284 ·Status: COMPLETED ·Phase: PHASE1
-
Polyglutamate Camptothecin in Treating Patients With Advanced Cancer
NCT00059917 ·Status: COMPLETED ·Phase: PHASE1
-
Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma
NCT05019716 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Fenretinide in Treating Patients With Metastatic or Unresectable Malignant Solid Tumors
NCT00387504 ·Status: COMPLETED ·Phase: PHASE1
-
Ph 1 Trial of ADI-PEG 20 Plus Docetaxel in Solid Tumors With Emphasis on Prostate Cancer and Non-Small Cell Lung Cancer
NCT01497925 ·Status: COMPLETED ·Phase: PHASE1
-
The Addition of Metformin to Definitive Radiotherapy in Patients With Stage III NSCLC
NCT04170959 ·Status: TERMINATED ·Phase: PHASE2
-
Paclitaxel Plus Topotecan in Treating Patients With Solid Tumors
NCT00002587 ·Status: COMPLETED ·Phase: PHASE1
-
Dasatinib and Lapatinib Ditolsylate in Treating Patients With Advanced Solid Tumors That Cannot Be Removed By Surgery
NCT00662636 ·Status: COMPLETED ·Phase: PHASE1
-
Paclitaxel Therapeutic Drug Monitoring in Cancer Patients
NCT03987555 ·Status: SUSPENDED
-
Clinical Study of Metronomic Oral Cyclophosphamide in Patients With Advanced Sarcomas
NCT01716689 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Protein-Bound Paclitaxel in Patients With Advanced Solid Tumors
NCT03129139 ·Status: RECRUITING ·Phase: PHASE1
-
To Determine the Effect of Food on the Pharmacokinetics of Olaparib and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation in Patients With Advanced Solid Tumours
NCT01921140 ·Status: COMPLETED ·Phase: PHASE1
-
Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors
NCT04234568 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia
NCT04803305 ·Status: COMPLETED ·Phase: PHASE1
-
Radiation Therapy, Chemotherapy, and Soy Isoflavones in Treating Patients With Stage IIIA-IIIB Non-Small Cell Lung Cancer
NCT01958372 ·Status: COMPLETED ·Phase: PHASE1
-
Docetaxel and Lapatinib in Metastatic Transitional Cell Carcinoma in Bladder
NCT01382706 ·Status: TERMINATED ·Phase: PHASE2
-
Bryostatin 1 Plus Paclitaxel and Cisplatin in Treating Patients With Advanced Solid Tumors
NCT00003242 ·Status: COMPLETED ·Phase: PHASE1
-
AFP464 in Treating Patients With Advanced Solid Tumors
NCT00369200 ·Status: TERMINATED ·Phase: PHASE1
-
Analyses of Human Samples Collected in Clinical Trials
NCT00339664 ·Status: COMPLETED
-
A Radiolabeled Mass Balance Study Of [14C]PF-00299804 In Healthy Male Volunteers
NCT01034748 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, Tolerability, Immunogenicity and Pharmacokinetics of ONC-841
NCT06219499 ·Status: WITHDRAWN ·Phase: PHASE1
-
Safety Study of a Cell Penetrating Peptide (p28) to Treat Solid Tumors That Resist Standard Methods of Treatment
NCT00914914 ·Status: COMPLETED ·Phase: PHASE1