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Association Between Insulin Resistance and Beta Cell Function With HbA1C in Diabetics

NCT03196154 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 255

Last updated 2018-07-19

No results posted yet for this study

Summary

Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin physiological response is reduced. Insulin resistance and beta cell function will be estimated through a mathematical model, homeostasis model assessment. Fasting insulin and C-peptide will be measured using liquid chromatography tandem mass spectrometry. Insulin resistance and beta cell function is then compared with the glycaemic control, HbA1C.

Conditions

  • Diabetes Mellitus, Type 2

Interventions

DIAGNOSTIC_TEST

Fasting insulin level

Fasting insulin and C-peptide level measured using LCMS which is then used to calculate the insulin resistance and beta cell function using homeostasis model assessment

DIAGNOSTIC_TEST

Plasma drug level

Plasma trough level of metformin and gliclazide will be measured using LCMS to ensure true compliance.

Sponsors & Collaborators

  • Ministry of Health, Malaysia

    collaborator OTHER_GOV

  • Clinical Research Centre, Malaysia

    lead OTHER

Principal Investigators

  • Aylwin Ming Wee Lim · Clinical Research Centre, Malaysia

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-08-01
Primary Completion
2018-03-30
Completion
2018-03-30

Countries

  • Malaysia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03196154 on ClinicalTrials.gov