MedTrace Logo

HYPOCHLOROUS ACID SUBSTANTIVITY AS ANTIPLAQUE AGENT (HOCl-SAP)

NCT03174756 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2017-10-26

No results posted yet for this study

Summary

Hypochlorous acid (HOCl) in a non-antibiotic antimicrobial agent used in clinical medicine. Nevertheless, its antiplaque oral effect has not been evaluated. Chlorhexidine (CHX) is the gold standard as an antiplaque agent for its high substantivity in plaque and saliva. There are no published studies evaluating the substantivity of hypochlorous acid compared to CHX. Objective: To evaluate the efficacy of mouthwashes of HOCl in substantivity evaluated by reduction of bacterial viability in saliva during 7 hours compared to CHX rinses and a placebo.

Conditions

  • Hypochlorous Acid
  • Mouthwashes

Interventions

DRUG

Hypochlorous Acid

Mouthwashes of antiplaque agents

DRUG

Chlorhexidine

A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

OTHER

Placebo

Sterile water as placebo

Sponsors & Collaborators

  • Universidad El Bosque, Bogotá

    lead OTHER

Principal Investigators

  • Gloria Ines Lafaurie, MS · El Bosque University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-15
Primary Completion
2016-11-15
Completion
2016-11-30

Countries

  • Colombia

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03174756 on ClinicalTrials.gov