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Oral Amantadine Versus Gabapentin to Attenuate the Response to Laryngoscopy and Tracheal Intubation

NCT03172234 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2018-09-25

No results posted yet for this study

Summary

To evaluate the effect of oral amantadine versus gabapentin premedication on the hemodynamic response to laryngoscopy and tracheal intubation and their effect on β-endorphins.

Conditions

  • Effect of Laryngoscopy and Tracheal Intubation

Interventions

OTHER

oral amantadine sulfate

In amantadine group:the patients will receive100 mg oral amantadine sulfate 90 minute prior to the surgery

DRUG

oral gabapentin

In gabapentin group: the patients will receive oral 800 mg gabapentin 90 minute prior to the surgery

DRUG

Placebo Oral Tablet

in control group : the patients will receive Placebo Oral Tablet 90 minute prior to the surgery

Sponsors & Collaborators

  • Ghada Mohammed AboelFadl

    lead OTHER

Principal Investigators

  • Abualauon Elpiplaoy, MD · Assiut University

  • Ahmed El shanawany, MD · Assiut University

  • Azza Abo Elfadl El Sayed, MD · Assiut University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-15
Primary Completion
2018-05-15
Completion
2018-05-15

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03172234 on ClinicalTrials.gov