CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)

Summary

Postnatal depression affects about 10-15% of women after childbirth. Approximately 3-5% of women experience a moderate-to-severe depression that requires medical attention. This study aims to investigate the implication of pain relief choice in reducing the postnatal depression of women who deliver their babies.

Conditions

• Depression, Postpartum
• Analgesia, Obstetrical
• Anesthesia, Obstetrical

Interventions

DEVICE

Epidural delivery system

Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.

DRUG

Entonox

Entonox will be given upon request in non-epidural group.

DRUG

Meperidine

Intramuscular pethidine (75mg/1.5ml) will be given upon request in non-epidural group.

DRUG

Ultiva

Intravenous patient controlled remifentanil (20-40mcg/ml) is only given when the patient rejects or cannot receive pethidine and entonox in non-epidural group..

DRUG

Fentanyl

Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.

DRUG

Ropivacaine

Epidural delivery system for maintenance of labour epidural analgesia using 0.1% ropivacaine (amide local anaesthetic) with 2mcg/ml fentanyl (opioid) as maintenance solution.

Sponsors & Collaborators

• KK Women's and Children's Hospital

  lead OTHER_GOV

Principal Investigators

• Ban Leong Sng, FANZCA · KK Women's and Children's Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

21 Years

Max Age

50 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-06-15

Primary Completion

2021-07-19

Completion

2026-12-31

Countries

• Singapore

Study Locations