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The ROAR Study: Reactive Oxygen Species and Reproduction

NCT06831019 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1100

Last updated 2026-02-17

No results posted yet for this study

Summary

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Conditions

  • Ovarian Aging
  • IVF Outcome
  • Oxidative Stress

Interventions

DIAGNOSTIC_TEST

Oxidative stress markers

We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes

Sponsors & Collaborators

Principal Investigators

  • Mitchell Rosen, MD · University of California, San Francisco

Eligibility

Min Age
18 Years
Max Age
43 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-07
Primary Completion
2027-03-01
Completion
2027-03-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06831019 on ClinicalTrials.gov