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Mitochondrial Energy Production in ART (Assisted Reproductive Technology )

NCT02727400 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2018-04-17

No results posted yet for this study

Summary

Oocyte maturation requires a lot of energy, which is provided by the mitochondria via the synthesis of ATP. The majority of patients with advanced maternal age (AMA) have poor egg quality. One of the reasons depends on oxidative phosphorylation of Pyruvate to undergo maturation; on the contrary, the cells of the cumulus (CC) show great activity glycolytic so that these cells are able to provide ATP(adenosine triphosphate and energy substrates to the oocyte. The goal of this work is to analyze the mitochondrial function and energy production in oocyte donors compared with a group of women of advanced maternal age subject to a same ovarian stimulation Protocol

Conditions

  • Female Infertility Due to Advanced Maternal Age

Sponsors & Collaborators

  • IVI Madrid

    lead OTHER

Principal Investigators

  • Juan A Garcia-Velasco, MD, PhD · IVI Madrid

Eligibility

Min Age
18 Years
Max Age
46 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-04-01
Primary Completion
2018-04-16
Completion
2018-04-16

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02727400 on ClinicalTrials.gov