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PAIR Study-PAP And IOP Relationship: Study 2

NCT03145129 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2018-06-06

No results posted yet for this study

Summary

Some people with Primary Open-angle Glaucoma (POAG) also suffer from Obstructive Sleep Apnoea (OSA), a common sleep disorder which is known to affect heart and blood vessels, and may contribute to glaucoma progression. Obstructive Sleep Apnoea is treated with Continuous Positive Airway Pressure (CPAP); however using this type of breathing support may raise intraocular pressure (IOP). The evidence for this is limited and the potential mechanisms involved are poorly understood.

In this study we will determine whether CPAP applied at night changes IOP and ocular perfusion pressure (OPP). We will also assess its possible impact on ocular microvasculature. Two groups of patients will be included: those with POAG and OSA, and those with OSA without glaucoma. They will attend for two overnight assessments: the first before starting CPAP and the second 4-6 weeks into the treatment. Repeated measurements of IOP at night will be performed and participants will continue self-measuring IOP at home in the day. An Ocular Coherence Tomography Angiography (OCT Angiography) of the optic disc and the surrounding retina will be performed at baseline and after a few weeks of CPAP treatment.

Conditions

  • Obstructive Sleep Apnoea
  • Primary Open-angle Glaucoma

Interventions

DEVICE

Continuous Positive Airway Pressure

Continuous Positive Airway Pressure

Sponsors & Collaborators

  • Hinchingbrooke Healthcare NHS Trust

    collaborator UNKNOWN

  • Papworth Hospital NHS Foundation Trust

    lead OTHER_GOV

Principal Investigators

  • Dariusz Wozniak, MBBS, MRCP · Papworth Hospital NHS Foundation Trust

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-03-24
Primary Completion
2018-02-10
Completion
2018-02-10

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03145129 on ClinicalTrials.gov