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Lung PGD Biomarkers in Organ Donors

NCT03089489 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2017-03-24

No results posted yet for this study

Summary

PGD is a syndrome characterized by alveolocapillary barrier structural and functional alterations with surfactant inactivation and vascular permeability increase, which cause lung edema, parenchymal infiltrate and progressive hypoxemia.

PGD may be enhanced in lung donor. Inflammatory and structural changes may be present in the lungs before organ recovery and/or after organ preservation. The investigators aim to identify the surfactant protein, inflammatory and structural changes in lung donor before and after cold ischemia, and biomarkers to PGD in lung recipients.

Conditions

  • Lung Transplant Failure

Interventions

DIAGNOSTIC_TEST

lung biomarkers in organ donor for PGD in lung recipient

Lung biopsies in organ donor before and after cold ischemia

Sponsors & Collaborators

  • University Hospital of Mont-Godinne

    lead OTHER

Principal Investigators

  • Asmae Belhaj, MD, PhD · CHU UCL Namur

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-04-01
Primary Completion
2022-03-08
Completion
2024-03-08

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03089489 on ClinicalTrials.gov