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Quantitative Parameters of HLA-DQ Antibodies in Lung Transplantation

NCT03474536 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2025-07-04

No results posted yet for this study

Summary

The aim is to compare the quantitative parameters of de novo anti-HLA DQ Donor Specific Antibodies (DSA), determined at the time of their discovery by surface plasmon resonance (SPR), between recipients that developed a Chronic Lung Allograft Dysfunction (CLAD) for the 2 years following DSA apparition and those who did not. If concentration, kinetics and/or affinity parameters of anti-DQ DSA are associated with CLAD development, new, non-invasive prognostic biomarkers of humoral rejection in lung transplantation will be discovered .

Conditions

  • Lung Transplantation
  • Antibody Mediated Rejection
  • Chronic Lung Allograft Dysfunction

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-14
Primary Completion
2025-04-08
Completion
2025-04-08

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03474536 on ClinicalTrials.gov