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Physiological Abnormalities Associated with Down Syndrome

NCT03087500 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2024-09-03

No results posted yet for this study

Summary

The overall goal of this study is to evaluate biomarkers of oxidative stress, mitochondrial function, and DNA methylation (epigenetics) in order to determine the extent to which these biomarkers are related to cognitive, behavioral and adaptive function in Down Syndrome. The inter-relationship between measurable biomarkers and functional/cognitive abilities will move beyond genetics to provide unprecedented new knowledge and a broader understanding of the underlying pathophysiology and abnormal gene expression induced by trisomy 21.

Conditions

  • Down Syndrome

Interventions

OTHER

There is no other intervention, only clinical treatment.

There is no other intervention, only clinical treatment.

Sponsors & Collaborators

  • Down Syndrome Research Foundation

    collaborator UNKNOWN

  • Arkansas Children Research Institute

    collaborator UNKNOWN

  • University of Arkansas

    lead OTHER

Principal Investigators

  • Richard Frye · Arkansas Childrens Research Institute

Eligibility

Min Age
3 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-10-01
Primary Completion
2017-10-01
Completion
2019-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03087500 on ClinicalTrials.gov