Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2

Summary

This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.

Conditions

• Charcot-Marie-Tooth Disease, Type Ia (Disorder)
• HMSN

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS)

  collaborator NIH

• Muscular Dystrophy Association

  collaborator OTHER

• University of Rochester

  collaborator OTHER

• University of Pennsylvania

  collaborator OTHER

• King's College Hospital NHS Trust

  collaborator OTHER

• Sydney Children's Hospitals Network

  collaborator OTHER

• Children's Hospital of Philadelphia

  collaborator OTHER

• University of Miami

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

  collaborator OTHER

• Cedars-Sinai Medical Center

  collaborator OTHER

• Nemours Children's Clinic

  collaborator OTHER

• Stanford University

  collaborator OTHER

• University of Minnesota

  collaborator OTHER

• Massachusetts General Hospital

  collaborator OTHER

• University of Colorado, Denver

  collaborator OTHER

• Children's National Research Institute

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• St. Jude Children's Research Hospital

  collaborator OTHER

• Connecticut Children's Medical Center

  collaborator OTHER

• Seattle Children's Hospital

  collaborator OTHER

• The Hospital for Sick Children

  collaborator OTHER

• University of Iowa

  lead OTHER

Principal Investigators

• Michael E Shy, MD · University of Iowa

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2010-05-31

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• United States
• Australia
• Canada
• Italy
• United Kingdom

Study Locations