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Effects of Ketones and Niacin in Heart Failure Patients

NCT04703361 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2021-12-03

No results posted yet for this study

Summary

Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial hemodynamics effect in patients with hearth failure with reduced ejection fraction. The mechanisms behind these marked hemodynamic effects are currently unknown, but could involve prostaglandin-release. 3-OHB is the endogenous ligand for the G protein-coupled receptor hydroxy-carboxylic acid 2 (HCA2) receptor. This receptor has proven downstream effects on cAMP and systemic effects via release of prostaglandins.

In this present study we will investigate the cardiovascular effects of HCA2-receptor stimulation in heart failure patients.

Conditions

  • Heart Failure, Systolic
  • Ketonemia

Interventions

BIOLOGICAL

Placebo NaCl

Placebo

BIOLOGICAL

Niacin

B3 vitamin, Niacin

BIOLOGICAL

Na-3-OHB

Na-3-OHB

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Nigopan Gopalasingam, MD · University of Aarhus

  • Henrik Wiggers, MD, PhD, DMSc · Aarhus University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-15
Primary Completion
2021-09-03
Completion
2021-09-03

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04703361 on ClinicalTrials.gov