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The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation

NCT03059862 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2023-04-13

No results posted yet for this study

Summary

This study evaluates the role of dietary L-tryptophan, an essential amino acid, in the activation of a specific cellular component: the aryl hydrocarbon receptor.

Conditions

  • Diet Modification

Interventions

DIETARY_SUPPLEMENT

L-tryptophan

3 g/day of L-tryptophan added to the standardized low-tryptophan diet. Duration: 3 weeks.

DIETARY_SUPPLEMENT

Placebo

A placebo will be added to the standardized low-tryptophan diet. Duration: 3 weeks.

Sponsors & Collaborators

  • National Research Agency, France

    collaborator OTHER

  • Canadian Institutes of Health Research (CIHR)

    collaborator OTHER_GOV

  • McMaster University

    lead OTHER

Principal Investigators

  • Premysl Bercik, MD, PhD · McMaster University, Department of Medicine, Division of Gastroenterology

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-11-01
Primary Completion
2018-04-30
Completion
2018-06-30

Countries

  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03059862 on ClinicalTrials.gov