Canola Oil Multi-center Intervention Trial II

Summary

Building on the findings from the investigators previous study, COMIT I, the purpose of the COMIT II study is to supplement the DEXA measurement of body composition with a supplementary DEXA measurement of visceral adipose tissue and to specifically target the impact of oleic acid consumption on body composition as the primary objective. COMIT II also will include analysis of fatty acid ethanolamines (FAEs) and their precursors to elucidate the mechanisms by which canola oil may be modifying body composition, measurement of endothelial function, inflammatory, adiposity and insulin sensitivity biomarkers, and genetic analyses.

Conditions

• Cardiovascular Disease
• Metabolic Syndrome

Interventions

OTHER

Canola Oil

Regular canola oil will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily.

OTHER

High oleic acid canola oil

High oleic acid canola oil will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily.

OTHER

Western diet oil combination

A typical "Western diet" fat intake as a control treatment, comprised of 11% MUFA, 11% PUFA (9% omega-6 fatty acids and 2% omega-3 fatty acids), and 13% SFA, will be iso-calorically incorporated into fruit smoothies made with milk and consumed twice daily

Sponsors & Collaborators

• Canola Council of Canada

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• Laval University

  collaborator OTHER

• Unity Health Toronto

  collaborator OTHER

• St. Boniface Hospital

  collaborator OTHER

• Penn State University

  lead OTHER

Principal Investigators

• Penny M Kris-Etherton, PhD · Penn State University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

20 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2014-09-30

Primary Completion

2016-11-30

Completion

2016-11-30

Countries

• United States

Study Locations