Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis
NCT03044223 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100
Last updated 2024-01-17
Summary
The present study focuses on patients with Pseudomonas aeruginosa (PSA) sepsis. The aim of the present study is to find out whether the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype predominates in blood monocytes in critically ill patients with PSA-sepsis, and whether the severity of sepsis and outcome is associated with distinct monocyte phenotype and function.
Conditions
- Pseudomonas Infections
- Pseudomonas Septicemia
- Pseudomonas; Pneumonia
- Pseudomonal Bacteraemia
- Pseudomonas Urinary Tract Infection
- Pseudomonas Gastrointestinal Tract Infection
- Sepsis
- Sepsis, Severe
- Critically Ill
Sponsors & Collaborators
-
University of Ulm
lead OTHER
Principal Investigators
-
Manfred Weiss, MD, MBA · University Ulm, University Hospital Ulm
-
Anne Sedlag, Biochemist · University Ulm, Institute of Microbiology and Biotechnology
Eligibility
- Min Age
- 18 Years
- Max Age
- 90 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2014-08-31
- Primary Completion
- 2025-11-30
- Completion
- 2026-12-31
Countries
- Germany
Study Locations
More Related Trials
-
Pro-inflammatory Cytokines Profile and Mortality Rate of Critically Ill Septic Patients Following Plasmapheresis
NCT01249222 ·Status: UNKNOWN ·Phase: NA
-
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
NCT00934011 ·Status: COMPLETED ·Phase: NA
-
CD64 and Antibiotics in Human Sepsis
NCT02922998 ·Status: COMPLETED
-
Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis
NCT00222222 ·Status: COMPLETED ·Phase: NA
-
Inflammatory Mediators in Early Sepsis
NCT02692118 ·Status: UNKNOWN
-
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis
NCT05110937 ·Status: RECRUITING
-
Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock
NCT04281277 ·Status: COMPLETED ·Phase: NA
-
Identification and Clinical Efficacy Analysis of Biomarkers in Sepsis Patients
NCT05911711 ·Status: UNKNOWN
-
Effect of Immunophenotype on Prognosis of Sepsis
NCT05602584 ·Status: UNKNOWN
-
Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.
NCT07200817 ·Status: RECRUITING
-
Early Procalcitonin Kinetics During Empirical Antibiotic Therapy in Critically Ill Patients
NCT02294695 ·Status: COMPLETED
-
Acute Phase Proteins as Early Markers in Sepsis
NCT00641355 ·Status: UNKNOWN
-
Platelet Reactivity in Septic Shock
NCT03716310 ·Status: COMPLETED
-
Following of Myeloid-derived Suppressor Cells (MDSC) in Severe Sepsis: What Relationship With Systemic Inflammatory Syndrome?
NCT02903082 ·Status: TERMINATED
-
CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients
NCT04049565 ·Status: COMPLETED
-
Sensitivity and Specificity of Leucocytes Profiling Versus Platelet Indices in Prediction of Clinical Outcome for Candidates With Sepsis. A Bi-centric Observational Clinical Trial
NCT06612307 ·Status: COMPLETED
-
Platelets to Lymphocytes Ratio in Sepsis
NCT05399225 ·Status: UNKNOWN
-
Procalcitonin to Shorten Antibiotics Duration in ICU Patients
NCT01379547 ·Status: UNKNOWN ·Phase: PHASE3
-
Evaluation of the Performance of a New Rapid Bacteremia Test in the Intensive Care Patient
NCT06241248 ·Status: COMPLETED
-
Dissecting How Peripheral Lymphocytes Are Lost During Sepsis
NCT03289312 ·Status: UNKNOWN
-
Descriptive Study of the Evolution in Proportion of Regulatory B Lymphocytes in Patients Hospitalized in Intensive Care for Severe Sepsis
NCT03115125 ·Status: UNKNOWN ·Phase: NA
-
Assessing Immune Dysfunction in Sepsis
NCT07154615 ·Status: RECRUITING
-
Effect of Renin-Angiotensin System on Platelet in Patient With Sepsis
NCT03952390 ·Status: COMPLETED
-
Peripheral Artery Disease and Sepsis Outcomes
NCT03372330 ·Status: UNKNOWN
-
Detection Of Monocytes/Macrophages Function And Tim-3 Expression In Septic Patients
NCT01801839 ·Status: COMPLETED