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Mapping Sound Propagation Through the Human Lung for Better Diagnosis

NCT03043898 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 62

Last updated 2020-11-05

No results posted yet for this study

Summary

This study investigates the propagation of sound from a source in the chest to the chest wall.

The methodology of the study will be to place a sound source at a known location in the chest and measure the acoustic response on the posterior chest wall with an acoustic sensor array.

The sound source will be created by playing sound down the working channel of a bronchoscope and located anatomically using direct imaging.

Subjects will be selected for the study by asking patients undergoing a bronchoscopy procedure whether they would be willing to take part in the experiment in addition to their standard procedure.

Procedures will take place in the Bronchoscopy Unit at Addenbrooke's hospital in Cambridge. The Unit runs regional speciality clinics in severe chronic obstructive pulmonary disease, asthma, lung cancer, bronchomalacia and interstitial lung disease and has a nationally significant interventional bronchoscopy service.

A subsidiary part of the study (Part A) will collect sound recordings from healthy volunteers and patients with common respiratory diseases using the same acoustic sensor array. This is to create a database of lung sounds and quantify inter-subject variability.

The study will last approximately 30 months.

Conditions

  • Bronchomalacia
  • Asthma
  • Lung Neoplasms
  • Lung Diseases, Interstitial
  • Pulmonary Disease, Chronic Obstructive

Interventions

OTHER

Lung sound transmission measurement

Sound at chest wall is recorded using a sensor array during the bronchoscopy procedure, while a sound is played down the working channel of the bronchoscope.

OTHER

Lung sound recording

Lung sounds are recorded using a sensor array.

Sponsors & Collaborators

  • Cambridge University Hospitals NHS Foundation Trust

    collaborator OTHER

  • Maximilian Nussbaumer

    lead OTHER

Principal Investigators

  • Pasupathy Sivasothy, PhD · Cambridge University Hospitals NHS Foundation Trust

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-14
Primary Completion
2020-04-23
Completion
2020-04-23

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03043898 on ClinicalTrials.gov