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Impact of Microparticles in Blood on Transfused Patient Outcomes

NCT03041974 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 280

Last updated 2017-02-03

No results posted yet for this study

Summary

During storage, red blood cells (RBCs) undergo changes collectively termed "Storage lesions". these changes may have an impact of the outcomes of transfused patients. One of these changes is the release of microparticles by RBCs and other blood cells types. The aim of the study is to (1) quantify red cell- and platelet-derived microparticles in RBC concentrates, and (2) evaluate the impact of transfused microparticles (MPs) on survival and post-transfusion complications in critical care patients participating in the ABLE trial (ISRCTN44878718).

Conditions

  • Critical Care

Interventions

PROCEDURE

Red Blood Cell transfusion

PROCEDURE

Microparticles quantification

Flow cytometric quantification of microparticles in transfused blood

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Besancon

    lead OTHER

Principal Investigators

  • Francine Garnache-Ottou, PharmD, PhD · Etablissement Français du Sang, Besançon

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2014-05-31
Completion
2014-11-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03041974 on ClinicalTrials.gov