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Prehospital Transfusion Strategy in Bleeding Patients

NCT04879485 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-11-18

No results posted yet for this study

Summary

The aim of study is to compare clinical and biochemical effect of three different transfusion strategies among patients with major hemorrhage requiring prehospital transfusion.

A) Present prehospital standard treatment including a mixture of plasma and Red blood cell transfusion (RBC) transfusion B) Red blood cell transfusion (RBC) only C) Plasma transfusion only

Hypothesis:

1. Transfusion strategy including a mixture of RBC and plasma is superior as compared with only plasma or only RBC strategy in terms of initial treatment of circulatory shock (expressed as base deficit).
2. Endothelial function and ability of clot formation is preserved to a greater extent in patients receiving plasma.

Conditions

Interventions

BIOLOGICAL

Blood products

Compare two different transfusion strategies against standard transfusion regimen

Sponsors & Collaborators

  • Norwegian Air Ambulance Foundation

    collaborator OTHER

  • Odense University Hospital

    collaborator OTHER

  • Copenhagen University Hospital, Denmark

    collaborator OTHER

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Christian Fenger-Eriksen · Aarhus Universityhospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-05-03
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04879485 on ClinicalTrials.gov