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Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy

NCT03031899 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 27

Last updated 2018-11-05

Study results available
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Summary

Abstract

Objective:

To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions.

Materials and method:

In our study 27 patients with 41 lesions were included. Since one patient had not quit the habit in the two weeks following initial examination and another lesion disappeared in the waiting period, 2 patients (3 lesions) were not included in the study. Out of 38 lesions diagnosed based on clinical criteria, 32 were leukoplakia, 5 lichen planus and 1 SCC. After initial examination they were subjected to Rose Bengal and Toluidine blue stain. If stained positive they were subjected to biopsy.

Conditions

  • Oral Leukoplakia
  • Oral Lichen Planus
  • Premalignant Lesion

Interventions

PROCEDURE

Biopsy

rose bengal stain and toluidine is applied over a premalignant lesion and positively stained lesions are subjected to biopsy.

DIAGNOSTIC_TEST

Rose Bengal

the lesions stained positive were subjected to biopsy

DIAGNOSTIC_TEST

toluidine blue

the lesions stained positive were subjected to biopsy

Sponsors & Collaborators

  • The Oxford Dental College, Hospital and Research Center, Bangalore, India

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2016-03-31
Completion
2016-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03031899 on ClinicalTrials.gov