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Effect on Periodontal Markers by Bleaching Intracoronal Technique

NCT02718183 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2016-03-24

No results posted yet for this study

Summary

OBJECTIVES: The aim of this clinical randomized, double-blind clinical study was to assess the markers levels of RANKL IL-1B and OPGL, involved in the external cervical resorption as a primary outcome, and change color effectiveness in patients undergoing intracoronary bleaching.

METHOD: 46 volunteers (50 teeth) participated with discoloration on non-vital teeth, with the endodontic treatment in good condition. Patients were randomly located into two study groups according to product G1 = 35% hydrogen peroxide (n = 25) and G2 = 37% carbamide peroxide (n = 25).

The intracameral bleaching was performed with a walking bleaching technique of 4 sessions Gingivocrevicular transudate samples were taken to determine levels of Il1b, RANKL, and OPGL with absorbent paper (Periopaper®), they are obtained from six sites per tooth bleaching: 3 vestibular and three palatine (mesial, middle and distal), in 6 opportunities:

Baseline, after 4-sessions of intracameral bleaching and a one week after treatment. Total proteins are quantified by Bradford ® system and from the eluted sample of RANKL, IL 1b and OPGL levels measured by ELISA (Quantikine®; R\&D Systems Inc.).

The color was evaluated in each session with Vita EasyShade spectrophotometer is used with the CIEL\*a\*b system to measure the total variation in color (ΔE), between the baseline and the different evaluation times.

Conditions

  • Discolored Teeth

Interventions

OTHER

Hydrogen Peroxide 35% (Opalescence Endo - Ultradent, USA)

bleaching teeth gel to intracameral use.

OTHER

carbamide peroxide 37% (Whiteness Superendo, FGM, Brazil).

bleaching teeth gel to intracameral use.

Sponsors & Collaborators

  • University of Chile

    lead OTHER

Principal Investigators

  • eduardo fernandez · University of Chile

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2015-10-31
Completion
2016-02-29

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02718183 on ClinicalTrials.gov