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Pharmacokinetics of Flucloxacillin Given by Continuous or Intermittent Infusion to ICU Patients

NCT02993575 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2018-10-23

No results posted yet for this study

Summary

The pharmacokinetics of flucloxacillin are expected to be different in ICU patients compared to non-ICU patients. The investigators will determine total and free flucloxacillin concentrations in 30 ICU patients, who will get continuous (n=10) or intermittent infusion (n=20) of flucloxacillin as standard care.

Full pharmacokinetic curves will be taken for individual patients on the intermittent dosing regimen and limited sampling will be taken for individual patients on the continuous dosing regimen on day 2 and 4.

Conditions

Interventions

DRUG

Flucloxacillin

Dose according to summary of product characteristics (SPC) or local protocols: intermittent and continuous infusion

Sponsors & Collaborators

  • Canisius-Wilhelmina Hospital

    collaborator OTHER

  • Rijnstate Hospital

    collaborator OTHER

  • UMC Utrecht

    collaborator OTHER

  • Tergooi Hospital

    collaborator OTHER

  • Gelderse Vallei Hospital

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-06-01
Primary Completion
2018-03-01
Completion
2018-04-01

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02993575 on ClinicalTrials.gov