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A Randomized Multicenter Study for Isolated Skin Vasculitis

NCT02939573 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-01-23

No results posted yet for this study

Summary

Multi-center sequential multiple assignment randomized trial comparing the effectiveness of three different standard of care treatment options for patients with isolated skin vasculitis.

Conditions

  • Primary Cutaneous Vasculitis
  • Cutaneous Polyarteritis Nodosa
  • IgA Vasculitis
  • Henoch-Schönlein Purpura

Interventions

DRUG

Colchicine

Randomized to colchicine 0.6 mg x 2/day

DRUG

Dapsone

Randomized to dapsone 150 mg/day

DRUG

Azathioprine

Randomized to azathioprine 2 mg/kg/day

Sponsors & Collaborators

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    collaborator NIH

  • National Center for Advancing Translational Sciences (NCATS)

    collaborator NIH

  • Office of Rare Diseases (ORD)

    collaborator NIH

  • University of Pennsylvania

    lead OTHER

Principal Investigators

  • Robert Micheletti, MD · University of Pennsylvania

  • Christian Pagnoux, MD, MPH, MSc · University of Toronto/Mount Sinai Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • United States
  • Canada
  • Japan

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02939573 on ClinicalTrials.gov