Dental Malocclusion and Craniofacial Development in OI

Summary

Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss and pain and difficulty getting around. People with moderate to severe OI may also be diagnosed with dentinogenesis imperfecta (DI). DI is characterized by grey or brown teeth that may chip and wear down and break easily. People with DI may also have skull and neck defects. These patients may have severe teeth misalignment resulting in clinically significant chewing problems. Teeth misalignment in OI is very hard to treat because of the quality and quantity of bone. The overall goal of this study is to improve dental health to improve the quality of life of people with OI.

Conditions

• Osteogenesis Imperfecta

Sponsors & Collaborators

• Shriners Hospitals for Children

  collaborator OTHER

• Hospital for Special Surgery, New York

  collaborator OTHER

• University of Nebraska

  collaborator OTHER

• Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

  collaborator OTHER

• Children's National Research Institute

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• Oregon Health and Science University

  collaborator OTHER

• Baylor College of Medicine

  lead OTHER

Principal Investigators

• Jean-Marc Retrouvey, D.M.D. · McGill University

• Reid Sutton, M.D. · Baylor College of Medicine

• Frank Rauch, M.D. · Shriners Hospital for Children

Eligibility

Min Age

10 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-08-31

Primary Completion

2027-12-31

Completion

2027-12-31

Countries

• United States
• Canada

Study Locations