MedTrace Logo

Urinary Biomarkers of OI Pathobiology

NCT02531087 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2025-12-01

No results posted yet for this study

Summary

Osteogenesis imperfecta (OI) is a rare inherited disorder that causes bones to break easily. Individuals with osteogenesis imperfecta break bones often and may have other problems, including hearing loss, dental problems, pain and difficulty getting around. Before the genetic cause of OI was known, OI was classified into four types. Each type was based upon the symptoms and severity of OI. In most people with OI, the cause is a change in one of the genes that makes a protein called type 1 collagen. Some doctors now classify OI both on how severe it is as well as which gene is causing OI. When people classify OI this way, there are more than 10 types of OI. The current laboratory testing to determine OI subtype involves the collection of blood and/or skin cells.

Conditions

Sponsors & Collaborators

  • Shriners Hospitals for Children

    collaborator OTHER

  • University of Nebraska

    collaborator OTHER

  • University of Washington

    collaborator OTHER

  • Baylor College of Medicine

    lead OTHER

Principal Investigators

  • Vernon Reid Sutton, M.D. · Baylor College of Medicine

  • Frank Rauch, M.D. · Shriners Hospital for Children

  • David Eyre, Ph.D. · University of Washington

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-17
Primary Completion
2019-08-31
Completion
2026-08-31

Countries

  • United States
  • Canada

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02531087 on ClinicalTrials.gov