Effects of Botanical Microglia Modulators in Gulf War Illness

Summary

The overall objective of this protocol is to test if Gulf War Illness (GWI) involves chronic inflammation that cannot be measured with typical techniques. The investigators will be observing the effects of nine different botanical compounds (supplements) that are known to suppress inflammation. If one of those supplements helps the symptoms of GWI, it will give the investigators information about what is wrong in people with GWI.

Conditions

• Gulf War Illness

Interventions

DIETARY_SUPPLEMENT

Boswellia Serrata

DIETARY_SUPPLEMENT

Curcumin

DIETARY_SUPPLEMENT

Epimedium

DIETARY_SUPPLEMENT

Fisetin

DIETARY_SUPPLEMENT

Luteolin

DIETARY_SUPPLEMENT

Nettle

DIETARY_SUPPLEMENT

Pycnogenol

DIETARY_SUPPLEMENT

Reishi Mushroom

DIETARY_SUPPLEMENT

Resveratrol

DIETARY_SUPPLEMENT

Placebo

Sponsors & Collaborators

• Congressionally Directed Medical Research Programs

  collaborator FED

• University of Alabama at Birmingham

  lead OTHER

Principal Investigators

• Jarred W Younger, PhD · University of Alabama at Birmingham

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Model

CROSSOVER

Eligibility

Min Age

39 Years

Max Age

65 Years

Sex

MALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-07-31

Primary Completion

2019-09-30

Completion

2022-09-30

Countries

• United States

Study Locations