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A Case Control Study to Identify the Role of Epigenetic Regulation of Genes Responsible for Energy Metabolism and Mitochondrial Function in the Obesity Paradox in Cardiac Surgery

NCT02908009 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2023-11-14

No results posted yet for this study

Summary

This is a prospective, single-centre case control comparison of expression of target genes responsible for energy utilisation, mitochondrial function and oxidative stress and levels of histone acetylation/ DNA methylation in obese and non-obese adult cardiac surgery patients. The study aims to test several inter-related hypotheses in a consecutive sequence of patients undergoing coronary artery bypass grafting.

Conditions

  • C.Surgical Procedure; Cardiac

Sponsors & Collaborators

  • University of Leicester

    lead OTHER

Principal Investigators

  • Gavin Murphy · University of Leicester

  • Filiberto Serraino · University of Leicester

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-09-09
Primary Completion
2024-10-07
Completion
2024-10-07

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02908009 on ClinicalTrials.gov