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Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

NCT02902224 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2016-09-15

No results posted yet for this study

Summary

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Conditions

  • Exploratory Behavior

Interventions

DIETARY_SUPPLEMENT

Tap water

300ml tap water via nasogastric tube

DIETARY_SUPPLEMENT

Glucose

300ml tap water with 75g glucose via nasogastric tube

DIETARY_SUPPLEMENT

Fructose

300ml tap water with 25g fructose via nasogastric tube

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Christoph Beglinger, Prof · University of Basel

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2016-08-31
Completion
2016-08-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02902224 on ClinicalTrials.gov