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The Effects of Bariatric Surgeries on Glucose Metabolism

NCT02823665 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2025-09-09

No results posted yet for this study

Summary

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

Conditions

  • Post Bariatric Surgery
  • Gastric Bypass
  • Sleeve Gastrectomy
  • Hypoglycemia After Gastric Bypass

Interventions

DRUG

Exendin-(9-39)

A physiological study to evaluate the role of GLP-1 on glucose metabolism and insulin secretin after glucose and protein ingestion.

DRUG

Atropine

A physiological study to evaluate the effect of neural activation on insulin secretion and glucose metabolism.

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • The University of Texas Health Science Center at San Antonio

    lead OTHER

Principal Investigators

  • Marzieh Salehi, MD, MS · The University of Texas Health Science Center at San Antonio

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-07-31
Primary Completion
2026-08-31
Completion
2027-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02823665 on ClinicalTrials.gov