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An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures

NCT02783404 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2022-05-24

No results posted yet for this study

Summary

Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens. Recently, the investigators have evaluated the efficacy of the intravenous administration of 1000/200 mg of amoxicillin/clavulanate for the prevention of bacteraemia following dental extractions. The results of this study suggest that is highly effective, and that it might be considered a first-line choice for patients at high-risk for infective endocarditis who undergo dental procedures and for whom antimicrobial prophylaxis is recommended. This new project aims to evaluate the effectiveness of oral amoxicillin/clavulanate in preventing post-dental extraction bloodstream infection.

Conditions

  • Bacteraemia
  • Endocarditis

Interventions

DRUG

Amoxicillin

Receiving 2 gr oral Amoxicillin before dental any manipulation and following endotracheal intubation

DRUG

Amoxicillin-Potassium Clavulanate

Receiving 2 gr/125 mg oral Amoxicillin-Potassium Clavulanate before any dental manipulation and following endotracheal intubation Intervention: Drug: Amoxicillin-Potassium Clavulanate

Sponsors & Collaborators

  • Hospital Clinico Universitario de Santiago

    collaborator OTHER

  • University of Santiago de Compostela

    lead OTHER

Principal Investigators

  • Pedro Diz, MD, DDS, PhD · Santiago de Compostela University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-27
Primary Completion
2021-12-01
Completion
2022-05-17

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02783404 on ClinicalTrials.gov