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An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures

NCT06422221 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2024-06-17

No results posted yet for this study

Summary

Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens. The last American Heart Association (AHA) and European Society of Cardiology (ESC) guidelines include several important changes, highlighting that clindamycin (CLI) is no longer recommended as an alternative to amoxicillin in those allergic to penicillin. This new project aims to evaluate the effectiveness of oral doxycycline in preventing post-dental extraction bloodstream infection.

Conditions

  • Bacteremia
  • Endocarditis

Interventions

DRUG

Clindamycin

Receiving 600 mg oral Clindamycin 1 hour before general anesthesia and before any dental manipulation

DRUG

Doxycycline

Receiving 100 mg oral Doxycycline 1 hour before general anesthesia and before any dental manipulation

Sponsors & Collaborators

  • Hospital Clinico Universitario de Santiago

    collaborator OTHER

  • University of Santiago de Compostela

    lead OTHER

Principal Investigators

  • Pedro Diz Dios · Santiago de Compostela University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-15
Primary Completion
2025-01-15
Completion
2025-06-30

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06422221 on ClinicalTrials.gov