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Maternal Serum Ferritin and Low Neonatal Birth Weight

NCT02738463 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 64

Last updated 2016-04-14

No results posted yet for this study

Summary

Intrauterine growth restriction ( IUGR )is defined as fetal growth slower than the normal growth potential of a specific fetus because of genetic or environmental factors. Recently several studies have highlighted the role of many biomolecules as markers for IUGR. Measurement of maternal serum ferritin has also been used as a predictive marker for increased risk of IUGR. Iron deficiency has its known deleterious effect in pregnancy but iron loading may be associated with oxidative damage to cells and tissues. It has been shown in various studies that lower level of transferritin receptor expression in placenta is associated with preeclampsia and IUGR. This can lead to decrease extraction of iron by placenta from maternal serum leading to increase maternal serum ferritin. This fetal iron deficiency leads to increase in fetal corticotropins and fetal cortisol, causing inhibition of fetal growth

Conditions

  • IUGR

Sponsors & Collaborators

  • Ain Shams University

    collaborator OTHER

  • Ain Shams Maternity Hospital

    lead OTHER

Principal Investigators

  • Hassan A Bayoumyi, MD · Ain Shams University

  • Sherif A Ashoush, MD · Ain Shams University

  • Haitham AM ElSabaa, MD · Ain Shams University

Eligibility

Min Age
20 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2016-09-30
Completion
2016-09-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02738463 on ClinicalTrials.gov