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Fertility Preservation in Prepubertal Boys: An Experimental Approach

NCT02529826 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2015-08-20

No results posted yet for this study

Summary

Due to remarkable advances in cancer treatments, the investigators are witnessing a growing population of long-term survivors of childhood malignancies. However, fertility in adult life may be severely impaired by gonadotoxic therapies. Since prepubertal boys cannot produce spermatozoa, banking of testicular tissue prior to gonadotoxic treatment is a crucial step towards fertility preservation for this population. Several centers around the world are now cryopreserving testicular tissue for prepubertal boys in anticipation that future technologies will allow the utilization of the banked samples for fertility restoration.

Testicular tissue cryopreservation has now emerged as the leading strategy for fertility preservation in prepubertal boys before gonadotoxic treatments. Fertility restoration can theoretically be obtained after allo-transplantation of testicular tissue fragments that preserve both the SSCs and the supporting microenvironment (spermatogonial stem-cell niche).

Conditions

  • Oncology [See Also, Affected System]

Interventions

PROCEDURE

Testicular Biopsy

An open testicular biopsy will be performed by an attending urologist under general anesthesia.

Sponsors & Collaborators

  • Hadassah Medical Organization

    lead OTHER

Principal Investigators

  • Doron Kabiri, MD · Hadassah Hebrew Medical Center

Study Design

Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
3 Months
Max Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-11-30
Primary Completion
2018-11-30
Completion
2018-11-30

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02529826 on ClinicalTrials.gov