Disulfiram in Recurrent Glioblastoma

Summary

Disulfiram (Antabuse®) is a well-tolerated, cheap, generic drug that has been in use since the 1950s to treat alcoholism. There is now an increasing amount of independent preclinical data to support disulfiram as an anticancer agent. The potency of disulfiram as an anticancer agent seems strengthened by copper.

The investigators aim is to investigate disulfiram and copper-supplement as add-on treatment in glioblastoma patients with recurrence receiving alkylating chemotherapy.

Conditions

• Glioma
• Glioblastoma

Interventions

DRUG

Disulfiram

Disulfiram 400 mg daily

DIETARY_SUPPLEMENT

Copper

nutritional supplement with copper, 2 mg daily

DRUG

Alkylating Agents

Alkylating antineoplastic agent

Sponsors & Collaborators

• St. Olavs Hospital

  collaborator OTHER

• Lund University Hospital

  collaborator OTHER

• Karolinska University Hospital

  collaborator OTHER

• University Hospital, Linkoeping

  collaborator OTHER

• Region Örebro County

  collaborator OTHER

• Ryhov County Hospital

  collaborator OTHER

• Uppsala University Hospital

  collaborator OTHER

• Sahlgrenska University Hospital

  lead OTHER

Principal Investigators

• Asgeir S Jakola, MD, PhD · Sahlgrenska University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-01-31

Primary Completion

2021-01-15

Completion

2021-01-15

Countries

• Norway
• Sweden

Study Locations