Reshaping the Path of Vascular Cognitive Impairment (VCI)

Summary

The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter health and improving cognitive function in older adults with vascular cognitive impairment, defined as the presence of cognitive impairment combined with cerebral small vessel disease, compared with a stretch and relaxation program.

Conditions

• Transient Ischemic Attack
• Vascular Cognitive Impairment
• Subcortical Vascular Dementia

Interventions

BEHAVIORAL

Resistance exercise training

Twelve months of twice-weekly resistance training program that will gradually progress in intensity. Each training session will be 60 minutes (10 minutes of warm-up, 40 minutes of training, and 10 minutes of cool-down).

BEHAVIORAL

Control: stretching and relaxation program

Twelve months of twice-weekly stretching and relaxation program that includes stretches, deep breathing and relaxation techniques, general core control exercises, and general posture and health education. Each session will be 60 minutes.

Sponsors & Collaborators

• University of British Columbia

  lead OTHER

Principal Investigators

• Teresa Liu-Ambrose, PhD, PT · University of British Columbia

• John Best, PhD · University of British Columbia

• Jennifer Davis, PhD · University of British Columbia

• Charlie Goldsmith, PhD · Simon Fraser University

• Ging-Yuek Robin Hsiung, MD, PhD · University of British Columbia

• Roger Tam, PhD · University of British Columbia

• Thalia Field, MD · University of British Columbia

• Kenneth Madden, MD · University of British Columbia

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

55 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-05-17

Primary Completion

2022-06-02

Completion

2022-06-02

Countries

• Canada

Study Locations