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Memory and Exercise Training Study in Older Adults With Subjective Memory Complaints

NCT02433691 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2018-05-02

No results posted yet for this study

Summary

This pilot study is a first step in a rapidly growing area of clinical research to create the most effective means to combat age-related losses in cognitive function through preventive lifestyle strategies such as physical exercise and memory training. This study will develop innovative simultaneous exercise and memory training programs in non-demented volunteers with subjective memory complaints (controls or MCI). Our primary goal is to assess the cognitive impact of 4-week memory training programs done twice weekly: 1. during simultaneous aerobic exercise (SIM-AR-MET), 2. sequentially after aerobic exercise (SEQ-AR-MET), or 3. without aerobic exercise (replaced with sequential stretching and toning) (SEQ-ST-MET). The investigators will also measure potential metabolic (e.g., glucose, lipid panel) and molecular (serum BDNF) mediators of observed cognitive changes in a subset of participants (those at the UCLA CTRC/IPCN site).

Conditions

  • Memory Impairment

Interventions

OTHER

simultaneous aerobic exercise

stationary bicycling at 65% of heart rate reserve for 30 minutes while receiving memory training.

OTHER

sequential aerobic exercise

stationary bicycling at 65% of heart rate reserve for 30 minutes followed by memory training.

OTHER

stretching and toning

anaerobic stretching and toning followed by memory training.

Sponsors & Collaborators

  • David Merrill, MD, PhD

    lead OTHER

Principal Investigators

  • Sarah McEwen, Ph.D. · UCSD

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2017-06-30
Completion
2017-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02433691 on ClinicalTrials.gov