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Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)

NCT05079464 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2026-04-13

No results posted yet for this study

Summary

People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or "primed" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.

Conditions

Interventions

OTHER

tDCS

All participants randomized to tDCS will receive active tDCS

OTHER

Exercise

Participants will exercise at Toronto Rehab.

OTHER

Sham stimulation

The same procedure for tDCS will be used for the sham condition, except without active current.

OTHER

Treatment as usual

Exercise education/ treatment as usual will include routine advice about physical activity.

Sponsors & Collaborators

  • Sunnybrook Health Sciences Centre

    lead OTHER

Principal Investigators

  • Krista Lanctôt, PhD · Sunnybrook Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-22
Primary Completion
2026-09-30
Completion
2026-12-31

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05079464 on ClinicalTrials.gov